KPV 10mg, Research Peptide Canada

Buy KPV in Canada from Anglo Peptides, a Canadian research-grade supplier of the melanocortin-derived tripeptide KPV. Every vial is produced in a cGMP-compliant facility, independently verified to ≥99% purity by third-party HPLC, and lyophilised for stability. Orders ship same-day in cold-pack packaging, arrive within 1 to 3 business days across Canada, and include a batch-specific certificate of analysis. The summary below reflects the published preclinical literature and is provided for laboratory research context only.

What Is KPV?

it is a synthetic tripeptide built from the amino acids lysine, proline and valine (Lys-Pro-Val). It corresponds to the C-terminal fragment, residues 11 to 13, of alpha-melanocyte-stimulating hormone (alpha-MSH), a thirteen-amino-acid neuropeptide with well-documented anti-inflammatory activity. KPV retains much of that anti-inflammatory character while lacking the central His-Phe-Arg-Trp message sequence that alpha-MSH uses to engage melanocortin receptors and drive pigmentation. Because of this, the peptide does not produce the melanogenic, skin-darkening effects associated with the full hormone, which makes it a useful tool for isolating anti-inflammatory signalling from melanocortin-receptor activity. It is commonly listed with CAS number 67727-97-3, molecular formula C16H30N4O4 and a molecular weight of roughly 342 g/mol (supplier-reported values).

Mechanism of Action

The research literature describes KPV as a modulator of inflammatory signalling that works through several complementary routes rather than a single receptor.

NF-κB inhibition. it’s principal described action is suppression of the NF-κB pathway. In intestinal epithelial cell models it lowers NF-κB activation triggered by pro-inflammatory stimuli such as IL-1β and TNF-α, reducing the downstream output of inflammatory cytokines.^[1]

Intracellular uptake through PepT1. A distinguishing feature of KPV is that it can be carried inside cells by the di- and tripeptide transporter PepT1, which is strongly expressed in inflamed intestinal epithelium and in immune cells. This lets the peptide act on the NF-κB pathway intracellularly rather than only at the cell surface.^[1]

MAP kinase modulation. In the same epithelial models the peptide decreased IL-1β-induced phosphorylation of the ERK1/2, JNK and p38 MAP kinases, signalling nodes that amplify inflammatory responses.^[1]

Melanocortin-receptor independence. Because KPV lacks the core message sequence, its anti-inflammatory effect does not depend on functional melanocortin receptors such as MC1R, and it carries no pigmentation activity.^[2][3]

Research Applications

The published evidence for it is predominantly preclinical, spanning cell culture and rodent models, and is concentrated in inflammation research.

Intestinal inflammation. The strongest body of work concerns models of inflammatory bowel disease. Orally administered KPV reduced inflammation in mouse models of colitis, improving mucosal integrity and lowering inflammatory cytokines.^[1][2]

Targeted oral delivery. Hyaluronic-acid-functionalised nanoparticles loaded with the peptide delivered the peptide to colonic epithelial cells and macrophages and alleviated ulcerative colitis in mice, reportedly achieving efficacy at far lower doses than free peptide.^[4]

General anti-inflammatory and antimicrobial research. alpha-MSH-derived peptides including the C-terminal sequence reduced leukocyte accumulation in a crystal-induced peritonitis model,^[5] and alpha-MSH and its C-terminal fragment have shown direct antimicrobial activity against organisms such as Staphylococcus aureus and Candida albicans in vitro.^[6]

State of the evidence. KPV has not been established in well-powered human clinical trials; the data are preclinical and should be treated as investigational. it is supplied strictly for laboratory research.

Stability, Solubility and Handling

Anglo Peptides supplies KPV as a lyophilised powder. For laboratory use it is typically reconstituted with sterile or bacteriostatic water, in which this short peptide is readily soluble. The lyophilised powder is best stored frozen at -20°C; once reconstituted, solutions are generally kept refrigerated, protected from light, and used within a few weeks, with repeated freeze-thaw cycles avoided. These notes apply to in-vitro and animal research only.

Product Specifications

• Compound: the peptide (Lys-Pro-Val), melanocortin-derived tripeptide
• Sequence: Lys-Pro-Val (alpha-MSH 11-13)
• CAS: 67727-97-3 (commonly reported)
• Molecular formula: C16H30N4O4 (commonly reported)
• Molecular weight: ~342 g/mol
• Purity: ≥99% by HPLC
• Size: 10 mg per vial
• Form: Lyophilised powder
• Testing: Independent third-party HPLC and mass spectrometry
• Documentation: Batch-specific certificate of analysis
• Origin: Made in Canada

Quality, Testing and Canadian Sourcing

Every batch of Anglo Peptides KPV is independently tested to ≥99% purity with a certificate of analysis tied to the specific lot you receive. Producing and finishing vials in Canada lets us verify the full labelled milligram content and ship quickly without customs delays. Read more on our Canadian sourcing page. it is also one of the peptides included in our KLOW blend, and researchers studying tissue repair often pair it with BPC-157, TB-500 and GHK-Cu.

Comparison With alpha-MSH and Related Peptides

KPV is best understood in relation to its parent hormone. alpha-MSH is a thirteen-amino-acid neuropeptide that engages all five melanocortin receptors and produces both anti-inflammatory and pigment-related effects. By isolating only the C-terminal three residues, the peptide preserves a substantial part of the anti-inflammatory signature while shedding the receptor-binding message sequence, which is why it does not drive melanogenesis. This separation is what makes KPV attractive as a research tool: it allows investigators to study melanocortin-associated anti-inflammatory signalling without the confounding pigmentary and cardiovascular effects of full-length agonists. it is also frequently contrasted with corticosteroids in inflammation models, since it appears to dampen stimulus-induced signalling rather than broadly suppress immune activity, and its uptake through the PepT1 transporter gives it a route of action that classical anti-inflammatory agents do not share.

Considerations for Research Use

Investigators working with KPV should note that reported activity spans a wide concentration range, with nanomolar effects described in some intestinal-epithelial cell systems and a variety of oral and parenteral dosing schemes used across rodent studies. That variability makes careful dose-response design and transparent reporting important when comparing results across laboratories. Because PepT1 expression is upregulated in inflamed tissue, the cellular context of an experiment can materially affect uptake and apparent potency, so models should be characterised accordingly. As with any short peptide, appropriate vehicle and untreated controls, confirmation of compound identity by mass spectrometry, and verification of purity for each lot are essential for interpretable, reproducible data. An under-dosed or impure preparation will shift any dose-response relationship, which is among the most common sources of irreproducible peptide research. Every Anglo Peptides batch ships with third-party HPLC verification and a lot-specific certificate of analysis so the material in the experiment matches the label.

Frequently Asked Questions

References

1. Dalmasso G, Charrier-Hisamuddin L, Nguyen HTT, Yan Y, Sitaraman S, Merlin D. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology. 2008;134(1):166-178. PubMed
2. Kannengiesser K, Maaser C, Heidemann J, et al. Melanocortin-derived tripeptide it has anti-inflammatory potential in murine models of inflammatory bowel disease. Inflamm Bowel Dis. 2008;14(3):324-331. PubMed
3. Brzoska T, Luger TA, Maaser C, Abels C, Bohm M. Alpha-melanocyte-stimulating hormone and related tripeptides: biochemistry, antiinflammatory and protective effects in vitro and in vivo. Endocr Rev. 2008;29(5):581-602. PubMed
4. Xiao B, Xu Z, Viennois E, et al. Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis. Mol Ther. 2017;25(7):1628-1640. PubMed
5. Getting SJ, Schioth HB, Perretti M. Dissection of the anti-inflammatory effect of the core and C-terminal (the peptide) alpha-melanocyte-stimulating hormone peptides. J Pharmacol Exp Ther. 2003;306(2):631-637. PubMed
6. Cutuli M, Cristiani S, Lipton JM, Catania A. Antimicrobial effects of alpha-MSH peptides. J Leukoc Biol. 2000;67(2):233-239. PubMed

Research use only. KPV supplied by Anglo Peptides is intended exclusively for licensed laboratory and academic research. It is not a drug, dietary supplement, or medical product, and is not for human consumption, diagnosis, or treatment.

Researchers who buy it from Anglo Peptides receive a vial verified to ≥99% purity, batch-tested by Janoshik Labs, and shipped from within Canada. Choose the 10mg size above.

Every order is filled and finished in Canada, then dispatched domestically with tracking. Vials ship discreetly and clear in days, not weeks — no customs holds and no border delays that stall a study.

Each batch is independently verified by Janoshik Labs before it is listed, so identity and purity are documented rather than assumed. A certificate of analysis is available on request, and every vial links back to the lot it came from.

For handling, store unopened vials frozen and reconstitute with bacteriostatic water only when a study calls for it. Keep the reconstituted solution refrigerated, avoid repeated freeze-thaw cycles, and label each vial with its reconstitution date so results stay reproducible.