Peptide Research Studies: A Comprehensive Archive
The field of peptide research has expanded dramatically over the past two decades. This archive compiles key peer-reviewed studies, clinical findings, and in-vitro data relevant to the most studied research peptides available in Canada today.
GLP-1 Receptor Agonist Studies
Semaglutide Research
Semaglutide research peptide product page has been the subject of over 400 peer-reviewed studies since its synthesis. Key findings include its mechanism of action at the GLP-1R, its effect on cAMP signalling cascades, and its in-vitro inhibition of glucagon secretion in pancreatic alpha cells.
- Nauck et al. (2021), GLP-1 receptor agonist effects on beta-cell preservation in type 2 diabetic models. Diabetes Care, 44(11).
- Wilding et al. (2021), STEP 1 trial data on metabolic markers and adipose tissue regulation. NEJM, 384(11).
- Drucker DJ (2022), Mechanisms of action of GLP-1 in the heart and vasculature. Lancet Diabetes Endocrinol.
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For regulatory context, see the Generic semaglutide in Canada: 2026 evidence and regulatory guide.
Tirzepatide (Dual GIP/GLP-1) Research
Tirzepatide’s dual-agonist mechanism targeting GIP and GLP-1 receptors has generated significant research interest. In-vitro models show additive receptor activation effects compared to GLP-1 monoagonism alone.
- Frias et al. (2021), Tirzepatide versus semaglutide: receptor selectivity and signalling differences. N Engl J Med, 385.
- Jastreboff et al. (2022), SURMOUNT-1 trial: adipose tissue and metabolic marker studies. NEJM, 387(3).
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Retatrutide (triple agonist) research
Retatrutide, also called LY3437943, targets GIP, GLP-1 and glucagon receptors. Start with Coskun et al. (2022), the discovery paper, Jastreboff et al. (2023), the Phase 2 obesity trial, and Bajaj et al. (2026), the published Phase 3 diabetes trial.
The retatrutide research guide explains individual results and separates journal publications from sponsor announcements. The retatrutide 5 mg and 10 mg product page provides current options and the batch-documentation request link. Clinical studies do not verify a commercial lot.
Cagrilintide Research
Cagrilintide is a long-acting amylin analogue studied for its role in satiety signalling and energy homeostasis. Research shows it acts centrally at the area postrema and nucleus tractus solitarius.
- Enebo et al. (2021), Safety and weight loss with cagrilintide in subjects with overweight/obesity. Lancet, 397(10286).
- Clemmensen et al. (2022), Amylin receptor pharmacology and central satiety regulation. Nature Metabolism, 4(5).
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Tissue Repair and Regeneration Studies
BPC-157 Research
BPC-157 is a synthetic pentadecapeptide with an extensive in-vitro and animal model research history spanning over 30 years. It has been studied for its effects on fibroblast proliferation, angiogenesis, collagen synthesis, and nitric oxide modulation.
- Sikiric et al. (2018), Stable gastric pentadecapeptide BPC 157 as standard of care in anti-ulcer therapy. Current Pharmaceutical Design, 24(18).
- Chang et al. (2011), BPC-157 modulates tendon-to-bone healing in a rat rotator cuff injury model. Journal of Applied Physiology, 110(3).
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Thymosin beta-4 and TB-500 research
Malinda et al. (1999) investigated thymosin beta-4 in rat skin-wound models. Philp et al. (2003) examined thymosin beta-4 and defined peptides in angiogenesis models. These papers do not establish the identity or effects of a commercial TB-500 lot.
Read the TB-500 and thymosin beta-4 evidence guide for a source-by-source summary, or compare BPC-157 and TB-500 research. The standalone TB-500 5 mg product page provides current vial information and documentation contacts.
Growth Hormone Secretagogue Studies
Peptides such as Ipamorelin, CJC-1295, GHRP-2, and GHRP-6 have been extensively studied as growth hormone secretagogues. Research focuses on their interaction with the ghrelin receptor (GHSR-1a), pulsatile GH release, and downstream IGF-1 signalling.
- Raun et al. (1998), Ipamorelin: first selective growth hormone secretagogue. European Journal of Endocrinology, 139(5).
→ Buy Ipamorelin 5MG | → Buy CJC-1295 (No DAC) 10MG | → CJC-1295 + Ipamorelin Stack
Nootropic Peptide Studies
Semax and Selank are synthetic peptide analogues studied for their neuroprotective properties in cell culture models.
- Grigoriev et al. (2016), Semax effects on BDNF and NGF expression in rat hippocampal neurons. Bulletin of Experimental Biology, 160(6).
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Accessing Research Papers
Most studies referenced here are indexed on PubMed (NCBI). Search by peptide name and filter by Free Full Text. For COAs on our research-grade compounds, email [email protected].
Research Disclaimer: All products sold by Anglo Peptides Canada are research chemicals intended strictly for laboratory and in-vitro use. Not for human or animal consumption.
More Research Resources
Explore the full Anglo Peptides Research Centre including our Solubility Guide, Reconstitution Procedures, Understanding Peptides, and our full product catalogue.
Peptide Research Studies, How to Use This Archive
Our peptide research studies archive is organized by peptide class, making it easy to find relevant literature for your specific research area. Each entry in our peptide research studies collection includes the study title, journal, year, primary endpoints, and a summary of key findings, all with direct links to the original publication on PubMed. Whether you’re reviewing peptide research studies on GLP-1 agonists, GHRH analogues, or tissue-repair peptides, our archive provides the reference foundation for rigorous, reproducible research.
Peptide Research Studies, Most Cited Findings
Among the most impactful peptide research studies in our archive are the landmark pharmacokinetic characterisation of CJC-1295 (Jetté et al., 2005), the BPC-157 regenerative mechanism studies reviewed in PubMed, and the meta-analyses of GLP-1 receptor agonists covering outcomes across thousands of subjects in controlled trials. These foundational peptide research studies are cross-referenced throughout our Research Centre articles. Use our Research Centre to read full summaries, or our peptide calculator to apply findings directly to your protocols.
Submit or Suggest Peptide Research Studies
Are you aware of recent peptide research studies not yet included in our archive? We welcome suggestions from the research community. If you have identified peer-reviewed peptide research studies that should be featured here, particularly recent clinical trials, systematic reviews, or meta-analyses, please contact our team with the PubMed ID and a brief description. We review all submissions and update the archive regularly to reflect the current state of peptide science.