Buy 5-Amino-1MQ in Canada in 10 mg or 50 mg research vials. 5-Amino-1MQ, short for 5-amino-1-methylquinolinium iodide, is a quinolinium small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT). It is stocked in the Anglo Peptides Canada catalogue for laboratory procurement, but it is not a peptide. The published compound-specific evidence comes from biochemical assays, cell models, pharmacokinetic work in rodents and mouse studies. Researchers have not established human efficacy or a validated human-use protocol.
Select the 10 mg or 50 mg option above to see the current 5-Amino-1MQ price in Canadian dollars. Each vial is sold for laboratory research only. Review the documentation for the supplied batch before starting an experiment.
5-Amino-1MQ Canada product specifications
| Compound | 5-Amino-1MQ |
|---|---|
| Full chemical name | 5-amino-1-methylquinolinium iodide |
| Research class | Quinolinium small-molecule NNMT inhibitor |
| CAS number | 42464-96-0 |
| Molecular formula | C10H11IN2 |
| Molecular weight | 286.11 g/mol for the iodide salt |
| Available vial sizes | 10 mg and 50 mg |
| Intended use | Laboratory and in-vitro research only |
| Evidence base | Biochemical, cell-culture and animal research; no established human efficacy |
Some pages list a mass near 159 g/mol because they describe the 5-amino-1-methylquinolinium cation without the iodide counter-ion. This listing identifies the iodide salt and reports its 286.11 g/mol formula mass. Researchers should match the product name, counter-ion, CAS number and batch documentation when comparing materials.
What does 5-Amino-1MQ inhibit?
NNMT is a cytosolic enzyme that transfers a methyl group from S-adenosylmethionine to nicotinamide, producing 1-methylnicotinamide and S-adenosylhomocysteine. Researchers study this reaction because it connects nicotinamide handling with cellular methyl-donor balance. NNMT expression and function vary by tissue and disease model, so findings from adipose tissue or cultured cells do not support a universal effect in every biological system.
A 2017 structure-activity study identified methylated quinolinium compounds as a low-micromolar NNMT-inhibitor scaffold. The authors reported an NNMT IC50 near 1 micromolar for 5-Amino-1MQ in their biochemical system. A later study found that the membrane-permeable compound reduced intracellular 1-methylnicotinamide in cultured cells and showed selectivity for NNMT at the concentrations tested. Assay conditions, species and matrix affect potency measurements, so researchers should use the original methods when setting analytical controls.
Published 5-Amino-1MQ research
Enzyme inhibition and cell models
The 2017 medicinal-chemistry paper established the quinolinium structure-activity series and measured NNMT inhibition across analogues. The 2018 Biochemical Pharmacology paper then evaluated membrane permeability, intracellular 1-methylnicotinamide and adipocyte-related endpoints. These papers support use of 5-Amino-1MQ as an experimental NNMT probe. They do not establish a clinical indication.
Diet-induced obesity mouse studies
Researchers tested 5-Amino-1MQ in diet-induced obese mice in several preclinical programs. The 2018 study reported changes in body weight, white-adipose-tissue mass, adipocyte size and plasma cholesterol under its experimental conditions. A 2021 study combined NNMT inhibition with a reduced-calorie diet and measured body composition, liver pathology and adipose-tissue metabolites. Another project examined diet, NNMT inhibition and the mouse gut microbiome.
A 2024 study dosed diet-induced obese mice for 28 days and assessed body composition, glucose tolerance, insulin sensitivity, liver histology, circulating markers, plasma pharmacokinetics and tissue distribution. The investigators reported dose-related effects in that mouse model and disclosed company relationships involving the compound-development program. Animal findings require independent replication and cannot predict safety or benefit in humans.
Pharmacokinetic research
A 2021 analytical study developed and validated an LC-MS/MS method for 5-Amino-1MQ in rat plasma and urine. The researchers used the assay to characterize intravenous and oral pharmacokinetics in rats and reported a mean oral bioavailability of 38.4 percent in their model. That value describes the study formulation, species and protocol. It does not provide a human dose or administration recommendation.
5-Amino-1MQ 10mg versus 50mg
The 5-Amino-1MQ 10mg and 5-Amino-1MQ 50mg options contain the same listed iodide salt. The difference is the mass of research material in each vial. A 10 mg vial may suit analytical qualification, method development or a small pilot study. A 50 mg vial may reduce the number of units needed for repeat assays, larger experimental matrices or multiple study conditions.
Choose the vial size from the experimental design, expected losses, control requirements and analytical method. Anglo Peptides does not provide dosing, injection, reconstitution or stacking instructions for 5-Amino-1MQ. Qualified researchers should follow an approved protocol, institutional safety rules and the batch documentation.
Quality documentation and Canadian ordering
Check the batch record rather than relying on a generic purity claim. The product name, vial strength, lot code, analytical method, reported result and report identifier should match the material received. Use the Anglo Peptides Certificate of Analysis directory or contact support with the product, strength and lot number to request the relevant record.
Both sizes belong in the Buy Peptides Canada catalogue under All Products. The catalogue includes peptides and a small number of other research compounds, so the product page states the chemical class instead of describing 5-Amino-1MQ as a peptide. Canadian fulfilment and location information appears in the research supply location guide.
Storage and laboratory handling
Keep unopened material sealed, dry and protected from light. Follow the storage conditions and expiry information supplied for the batch. Researchers should use appropriate personal protective equipment, a documented weighing method and institutional procedures for chemical handling. Solubility, solution stability and compatible solvents depend on the study matrix and should be established in the laboratory rather than inferred from peptide-reconstitution guidance.
Do not use the sitewide peptide calculator for this compound. 5-Amino-1MQ has no amino-acid sequence, and peptide-specific handling assumptions do not apply.
Research evidence and limitations
The current literature supports 5-Amino-1MQ as a preclinical research tool for NNMT inhibition. Compound-specific studies include biochemical assays, cultured cells, rodent pharmacokinetics and mouse disease models. Published work has not established safety, efficacy, pharmacokinetics or a therapeutic dose in humans. Researchers should avoid translating rodent doses or outcomes into personal-use claims.
Review the primary papers, methods, supplementary data and conflicts-of-interest statements before designing a study. The Anglo Peptides Research Centre provides additional background on research compounds and laboratory documentation.
Frequently asked questions
Is 5-Amino-1MQ a peptide?
No. 5-Amino-1MQ is a quinolinium small molecule supplied here as the iodide salt. It has no amino-acid sequence.
What is the primary research target?
Published compound-specific studies identify nicotinamide N-methyltransferase, or NNMT, as the primary target. NNMT catalyzes nicotinamide methylation using S-adenosylmethionine.
What is the difference between 5-Amino-1MQ 10mg and 50mg?
Both options list the same compound. The vial contains either 10 mg or 50 mg of research material. Researchers should choose the quantity required by their approved study plan.
Does 5-Amino-1MQ have human clinical evidence?
The product-specific evidence cited here is preclinical. Researchers have not established human efficacy, safety or a validated therapeutic dose.
Why do molecular-weight values differ between websites?
The iodide salt has a formula mass of 286.11 g/mol. A value near 159 g/mol omits the iodide counter-ion and describes the quinolinium cation. Match the listed chemical form and CAS number when comparing products.
Is a Certificate of Analysis available?
Researchers can request batch documentation using the product name, vial strength and lot code. The report should identify the tested sample, method, result and report number.
How should unopened 5-Amino-1MQ be stored?
Keep the vial sealed, dry and protected from light, then follow the batch-specific storage instructions. A laboratory should validate solution handling for its own matrix and protocol.
Can the peptide calculator be used for 5-Amino-1MQ?
No. This compound is not a peptide, and the sitewide peptide calculator does not describe its preparation or use.
References
- Neelakantan H, et al. Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase. Journal of Medicinal Chemistry. 2017;60(12):5015-5028.
- Neelakantan H, et al. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high-fat-diet-induced obesity in mice. Biochemical Pharmacology. 2018;147:141-152.
- Awosemo O, et al. Development and validation of an LC-MS/MS assay for 5-amino-1-methylquinolinium in rat plasma. Journal of Pharmaceutical and Biomedical Analysis. 2021;203:114255.
- Combined nicotinamide N-methyltransferase inhibition and reduced-calorie diet normalizes body composition and enhances metabolic benefits in obese mice. 2021.
- Reduced-calorie diet combined with NNMT inhibition establishes a distinct microbiome in diet-induced obese mice. 2022.
- Nicotinamide N-methyltransferase inhibition mitigates obesity-related metabolic dysfunction. 2024.
Research use only: Anglo Peptides supplies 5-Amino-1MQ for laboratory and in-vitro research. It is not a drug, food, dietary supplement or cosmetic. It is not intended for human or veterinary use, consumption, diagnosis, treatment or administration.
Chris D. –
5-Amino-1MQ is getting a lot of attention in metabolic research and Anglo Peptides is one of the few Canadian sources that carry it. Good purity documentation, arrived intact and well-sealed. Fast Xpresspost delivery.
Rachel T. –
Ordered 5-Amino-1MQ for ongoing research into NAD+ metabolism. Anglo’s version is properly lyophilized, COA posted on the product page. Reliable Canadian source with fast same-day shipping.
James P. –
Very pleased with the quality here. 5-Amino-1MQ arrived perfectly intact, reconstituted cleanly, and the shipping tracking came through within hours of payment. Anglo Peptides is now my go-to Canadian source.