Epithalon 10mg, Research Peptide Canada

Buy Epithalon in Canada from Anglo Peptides, a Canadian research-grade supplier of the tetrapeptide bioregulator Epithalon (also spelled Epitalon). Every vial is produced in a cGMP-compliant facility, independently verified to ≥99% purity by third-party HPLC, and lyophilised for stability. Orders ship same-day in cold-pack packaging, arrive within 1 to 3 business days across Canada, and include a batch-specific certificate of analysis. The summary below reflects the published preclinical literature and is provided for laboratory research context only.

What Is Epithalon?

Epithalon is a synthetic tetrapeptide with the sequence alanine-glutamic acid-aspartic acid-glycine (Ala-Glu-Asp-Gly, abbreviated AEDG). It was developed by Vladimir Khavinson and colleagues at the St. Petersburg Institute of Bioregulation and Gerontology in Russia as a defined synthetic analogue designed to reflect the active amino-acid composition of Epithalamin, a polypeptide complex originally extracted from the pineal gland. It is listed with CAS number 307297-39-8, molecular formula C14H22N4O9 and a molecular weight of roughly 390 g/mol. Epithalon is one of the most-studied compounds in the short peptide bioregulator family, particularly in the context of telomere biology and gerontology research.

Mechanism of Action

The mechanistic claims for Epithalon should be read as proposals drawn largely from a single research program, supported mainly by cell-culture and animal work.

Telomerase activation in cell culture. The most-cited finding is that adding the peptide to telomerase-negative human fetal fibroblast cultures induced expression of the telomerase catalytic subunit (hTERT), increased telomerase activity and lengthened telomeres, with treated cells reportedly exceeding the usual replicative limit.^[1] It is important to note that telomerase induction in cultured cells does not demonstrate telomerase activation in adult human tissue, and independent replication outside the originating group is limited.

Pineal and circadian signalling. As a synthetic analogue of pineal Epithalamin, the peptide is proposed to influence melatonin secretion and normalise circadian and neuroendocrine function in aged animals.^[3]

Antioxidant effects. Reductions in oxidative and free-radical markers have been reported in animal studies.^[2]

Research Applications

Published findings for Epithalon are preclinical, spanning cell culture and rodent models.

Telomere and telomerase biology. Epithalon is used as a tool compound in studies of telomerase induction and replicative lifespan in cultured human cells.^[1]

Gerontology and aging models. Work from the originating group studied effects on aging biomarkers, lifespan, chromosome-aberration frequency and spontaneous tumour incidence in rodents, with mixed results across endpoints.^[2][4] A recent overview summarises the literature and its limitations.^[5]

State of the evidence. The foundational and mechanistic evidence originates largely from one research group, independent corroboration is limited, and there is no robust placebo-controlled human trial measuring telomere length before and after administration. Epithalon should be treated as an investigational research compound and is supplied for laboratory use only.

Stability, Solubility and Handling

Anglo Peptides supplies Epithalon as a lyophilised powder. For research it is reconstituted with sterile or bacteriostatic water, in which this small peptide is readily soluble. Store the lyophilised powder sealed, desiccated and protected from light, with long-term storage at -20°C; keep reconstituted solution refrigerated and use within a few weeks, avoiding repeated freeze-thaw cycles. These notes apply to in-vitro and animal research only.

Product Specifications

• Compound: Epithalon (Ala-Glu-Asp-Gly, AEDG), tetrapeptide bioregulator
• Sequence: Ala-Glu-Asp-Gly
• CAS: 307297-39-8
• Molecular formula: C14H22N4O9
• Molecular weight: ~390 g/mol
• Purity: ≥99% by HPLC
• Size: 10 mg per vial
• Form: Lyophilised powder
• Testing: Independent third-party HPLC and mass spectrometry
• Documentation: Batch-specific certificate of analysis
• Origin: Made in Canada

Quality, Testing and Canadian Sourcing

Every batch of Anglo Peptides Epithalon is independently tested to ≥99% purity with a lot-specific certificate of analysis. Producing and finishing vials in Canada lets us verify the full labelled milligram content and ship quickly without customs delays. Read more on our Canadian sourcing page. Researchers studying the Khavinson short-peptide bioregulators often examine Epithalon alongside Pinealon and Thymalin.

Epithalon, Epithalamin and the Telomere Question

Epithalon was designed as a defined synthetic stand-in for Epithalamin, a polypeptide complex originally extracted from the pineal gland and studied by the same research program for its proposed effects on aging and neuroendocrine function. Reducing that complex preparation to a single four-residue sequence, Ala-Glu-Asp-Gly, made it possible to study a reproducible molecule rather than a variable extract, and this is part of why Epithalon became the most-referenced compound in the short peptide bioregulator field. The interest that surrounds it centres on a single striking observation: in telomerase-negative human fibroblast cultures, the peptide was reported to induce telomerase and lengthen telomeres. That result is genuinely notable, but it is also frequently over-interpreted. Telomerase induction in a culture dish does not establish that the peptide activates telomerase in the tissues of a living adult, and the finding has had limited independent replication. The honest framing for research is that Epithalon is an interesting tool for studying telomere biology and pineal-axis questions, not a demonstrated intervention in human aging.

Considerations for Research Use

Because much of the Epithalon literature originates from one group and spans heterogeneous endpoints, careful experimental design matters. Studies intended to probe the telomerase claim should include appropriate controls and, ideally, independent readouts of telomerase activity and telomere length rather than a single assay. Dose-response work should be drawn from the concentrations reported in the primary cell-culture and rodent studies. As with any short peptide, confirmation of identity by mass spectrometry and verification of purity for each lot are essential, since an impure or under-dosed preparation will distort results. Every Anglo Peptides batch ships with third-party HPLC verification and a lot-specific certificate of analysis so the material matches the label.

Reconstitution, Storage and Handling in Detail

For laboratory use, the lyophilised powder is typically brought to room temperature before opening to avoid condensation, then reconstituted by adding sterile or bacteriostatic water slowly down the inside wall of the vial rather than directly onto the powder, and swirled gently rather than shaken to limit foaming and shear stress. The choice of diluent depends on the study: sterile water is common for single-session work, while bacteriostatic water, which contains a small amount of benzyl alcohol, is often preferred when a solution will be drawn from over several days. Once reconstituted, the solution is kept refrigerated at 2 to 8 degrees Celsius, protected from light, and used within a defined window, with aliquoting into single-use portions the most reliable way to avoid the repeated freeze-thaw cycles that degrade peptides. The lyophilised powder itself is far more stable than any solution and is best stored frozen, sealed and desiccated, for long-term holding. These are general research-handling conventions; the lot-specific certificate of analysis and its storage guidance should always take precedence for a given batch.

Frequently Asked Questions

References

1. Khavinson VKh, Bondarev IE, Butyugov AA. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003;135(6):590-592. PubMed
2. Anisimov VN, Khavinson VKh, Provinciali M, et al. Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. Biogerontology. 2003;4(4):193-202. PubMed
3. Khavinson VKh. Peptides and Ageing. Neuro Endocrinol Lett. 2002;23 Suppl 3:11-144. PubMed
4. Anisimov VN, Khavinson VKh. Peptide bioregulation of aging: results and prospects. Biogerontology. 2010;11(2):139-149. PubMed
5. Lawniczak A, et al. Overview of Epitalon – Highly Bioactive Pineal Tetrapeptide with Promising Properties. (Review). 2025. PubMed

Research use only. Epithalon supplied by Anglo Peptides is intended exclusively for licensed laboratory and academic research. It is not a drug, dietary supplement, or medical product, and is not for human consumption, diagnosis, or treatment.

Researchers who buy Epithalon from Anglo Peptides receive a vial verified to ≥99% purity, batch-tested by Janoshik Labs, and shipped from within Canada. Choose the 10mg size above.