Retatrutide 5mg, 10mg, 30mg & 60mg — Research Peptide Canada
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RESEARCH PEPTIDE

Retatrutide (Reta) Research Peptide Canada — 5mg to 60mg

Vial amounts5 / 10 / 30 / 60 mg
CompoundRetatrutide
FormatLyophilized powder

Price range: $63.99 through $297.99

In Stock

Buy retatrutide research peptide in Canada from Anglo Peptides. Choose a 5 mg, 10 mg, 30 mg or 60 mg lyophilized vial and select a size to see its current CAD price and stock. Request the matching batch COA and review Canadian shipping information. For laboratory research only; not for human or veterinary use.

Retatrutide research: clinical trials and 2026 results · Retatrutide vs tirzepatide

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Last updated · Reviewed against PubMed, trial registries and regulator sources

Retatrutide price in Canada

Prices are in Canadian dollars per lyophilized vial. Larger vials cost less per milligram.

Vial sizePrice (CAD)Price per mgStock
5 mg$63.99$12.80In stock
10 mg$87.99$8.80In stock
30 mg$187.99$6.27In stock
60 mg$297.99$4.97In stock

Retatrutide clinical trial status (2026)

Retatrutide (LY3437943) is an investigational Eli Lilly compound that activates the GIP, GLP-1 and glucagon receptors. It has not been approved by Health Canada and is sold here for laboratory research only.

  • Phase 2 (Jastreboff et al., NEJM 2023): 338 adults with obesity; mean weight reduction of 24.2% at 48 weeks on 12 mg.
  • Phase 3 TRIUMPH-1 (Lilly, May 2026): 2,339 adults; mean weight reduction of 28.3% at 80 weeks on 12 mg, versus 2.2% on placebo.
  • Phase 3 TRIUMPH-2 and TRIUMPH-3 (Lilly, July 2026): 80 weeks on 12 mg; 20.8% vs 4.0% on placebo in adults with type 2 diabetes (n=1,152) and 22.6% vs 3.2% in adults with severe obesity and cardiovascular disease (n=1,949).
  • Lilly says it plans to submit retatrutide to the FDA in the first quarter of 2027.

Phase 3 percentages are the sponsor's efficacy-estimand results (participants who stayed on treatment), as reported in Lilly press releases.

More detail: retatrutide dosage and reconstitution guide · retatrutide vs semaglutide vs tirzepatide

Reta Peptide: Product Specifications and Research Context

Anglo Peptides Canada supplies retatrutide research peptide in 5 mg, 10 mg, 30 mg and 60 mg lyophilized vials for Canadian laboratories. Retatrutide, often shortened to reta peptide, appears in the scientific literature as LY3437943. Each size describes the nominal contents of one vial, not a clinical dose or treatment recommendation.

Listed vial amounts 5 mg, 10 mg, 30 mg and 60 mg; availability varies by option.
Product form Lyophilized powder for laboratory research.
Price and availability Prices are shown in Canadian dollars. Select a vial size above for its current price and stock status.
Analytical documentation Request the COA for the current product and lot. Check that the report identifies the same batch as the vial.
Shipping Read shipping options and delivery terms. Delivery timing depends on the destination and carrier.

Retatrutide Mechanism and Current Evidence

Retatrutide acts at three receptors: GIP, GLP-1 and glucagon. Semaglutide targets GLP-1; tirzepatide targets GIP and GLP-1. The additional receptor activity makes retatrutide a distinct research compound. It does not establish that it will outperform another compound in every experiment or clinical setting. The original discovery study describes its pharmacology.

Current retatrutide research

Evidence checked September 6, 2026. Peer-reviewed evidence now includes the 2023 obesity trial, the 2024 liver-fat substudy and the June 2026 Phase 3 TRANSCEND-T2D-1 trial in type 2 diabetes. Lilly has also announced results from the TRIUMPH obesity program; sponsor announcements and full journal reports carry different levels of detail.

The studies concern an investigational medicine used under trial conditions; they do not verify the identity, sterility, safety or clinical equivalence of an online research vial. Read the Lancet Phase 3 paper.

The Research Use tab summarizes individual studies and their limits. For the complete timeline, results and Canadian status, read the retatrutide clinical trials and research guide.

Purity, Batch COA and Third-Party Testing

Start with the compound name and lot number, then check the testing laboratory, report date and methods. A chromatographic purity percentage is different from measured vial content. Mass-spectrometry evidence, quantity, sterility and endotoxin results answer different questions and should be read separately when reported.

Use the Certificate of Analysis request form to obtain the report for your retatrutide vial. Include the exact vial size and ask for the current shipping batch, or provide the lot code from your vial. If the directory does not list your size, enter it in the request message. Match the laboratory report to the supplied lot before relying on a specific test claim. The molecular references in the Specifications tab describe the literature compound and do not certify the contents of a particular vial.

Anglo Peptides offers the same research compound as lyophilized powder in 5 mg, 10 mg, 30 mg and 60 mg vials. The difference between these options is the nominal amount per vial. Vial amount does not describe a prepared solution’s concentration; laboratory staff calculate that from the amount of material and final solution volume. For the current retatrutide price in Canada, select a size above to view its CAD price and stock status. Compare vial amount and batch documentation alongside price when planning laboratory purchases.

Use the tirzepatide vs retatrutide research comparison to compare evidence and receptor targets. The semaglutide, tirzepatide and retatrutide overview adds the single-receptor comparator. Product options are grouped in the metabolic and fat-loss research category.

Buying retatrutide online in Canada

Select a vial size to check the current retatrutide price in Canada, stock status and available quantity. Review the matching batch documentation and Canadian shipping terms before ordering. To compare other laboratory materials, browse Buy Peptides Canada.

Reconstitution, Stability and Laboratory Storage in Canada

Follow the vial label, batch documentation and your laboratory’s validated handling procedure. Before reconstitution, confirm the material form, solvent compatibility and storage requirements for the supplied lot. Request missing handling information from Anglo Peptides support before preparing the material.

This page does not establish a universal storage temperature, shelf life or stability period after reconstitution. Laboratory staff should document the solvent, concentration, preparation date and storage conditions, and use stability data applicable to their method. The Specifications tab provides the molecular reference and batch-documentation requirements.

Use the peptide calculator to check mass, volume and concentration calculations for an established laboratory protocol. The calculator does not determine solvent compatibility, stability or a suitable research method.

Research use only. Retatrutide remains investigational. This product is not supplied as an approved medicine, and clinical trial results do not authorize human or veterinary use. Current developer status.

Retatrutide specifications and molecular reference

Product options5 mg, 10 mg, 30 mg and 60 mg nominal vial contents; consult the live selector.
Physical formLyophilized powder.
Literature nameRetatrutide; development code LY3437943; commonly called reta.
Reference peptide length39 amino-acid residues, with chemical modifications described in the original discovery paper.
Reference molecular formulaC221H342N46O68.
Reference molecular weightApproximately 4,731 g/mol, for the molecular representation in PubChem CID 171390338.
Receptor targetsGIP receptor, GLP-1 receptor and glucagon receptor.
Batch identity and purityCheck the matching laboratory report. Reference values do not verify a particular lot, counterion, water content or vial quantity.
Storage and stabilityFollow the vial label and batch documentation. No universal shelf life or post-reconstitution stability period is established by this page.
Intended useLaboratory research only; not for human or veterinary use.

Reference sources: PubChem CID 171390338 and Coskun et al. (2022). Formula and approximate molecular weight are literature identifiers; they are not presented as measured batch results. A shortened sequence fragment cannot identify the complete modified peptide.

Request the retatrutide batch COA for the supplied material’s analytical details. Solvent choice and stability depend on the laboratory’s validated method and the documented material form.

Last updated · Reviewed against PubMed, trial registries and regulator sources

Retatrutide studies: what the evidence shows

Checked November 5, 2026. The entries below distinguish published trials, secondary analyses and sponsor announcements. Reported study-arm amounts describe the trials, not how to use a research vial.

2022: discovery and early pharmacology

Coskun et al., Cell Metabolism described LY3437943 as a 39-residue agonist at GIP, GLP-1 and glucagon receptors, with preclinical and early clinical evidence. This establishes research context for the molecule, not a test result for the product batch.

2023: randomized Phase 2 obesity trial

Jastreboff et al., NEJM studied 338 adults. At 48 weeks, mean weight change in the 12 mg study arm was −24.2%, versus −2.1% with placebo. The primary endpoint was at 24 weeks. Gastrointestinal effects were common, and heart-rate increases were reported. Results cannot be assumed for another population or product.

2024: liver-fat substudy

Sanyal et al., Nature Medicine assessed 98 participants with elevated liver fat. MRI measurements improved in the study groups. This was a liver-fat endpoint, not evidence that retatrutide cures cirrhosis or prevents liver-related death.

June 2026: published Phase 3 TRANSCEND-T2D-1

Bajaj et al., The Lancet reported a placebo-controlled diabetes trial with HbA1c as its primary endpoint. The research guide explains its results and analysis method. Assess the trial medicine and a commercial research vial separately; publication does not verify a retail batch.

June and July 2026: TRIUMPH sponsor reports

Lilly’s June TRIUMPH-1 update reported 28.3% mean weight reduction in the 12 mg arm at 80 weeks. Its 104-week extension involved a selected population and should be identified separately. July TRIUMPH-2 and TRIUMPH-3 results concerned different populations with diabetes or severe obesity. These are sponsor-reported results, not a direct comparison with tirzepatide.

August 2026: cardiovascular risk biomarkers

The Diabetes, Obesity and Metabolism analysis examined lipid and inflammatory markers from two earlier Phase 2 trials. It was a post-hoc analysis. Changes in risk markers do not establish fewer heart attacks, strokes or cardiovascular deaths.

For trial populations, endpoint interpretation and the status of the head-to-head study, see the retatrutide research and clinical trials guide. Laboratory decisions also require the batch-specific analytical record; published clinical results do not establish that a research vial is clinically equivalent to the trial medicine.

2026 research update: retatrutide Phase 3 results

Since our September review, Eli Lilly has reported more Phase 3 readouts, including the first head-to-head trial against semaglutide. The figures below are from trials of Lilly's investigational medicine. They describe study arms and populations, not instructions for a research vial, and most are sponsor announcements that are not yet peer-reviewed.

TrialPopulationReported result
Phase 2 obesity (NEJM 2023)338 adults with obesity, 48 weeks−24.2% mean weight change in the 12 mg arm vs −2.1% placebo
TRIUMPH-4 (Dec 2025)Obesity with knee osteoarthritisMean weight reduction up to 28.7% (about 71 lb) at the highest dose
TRIUMPH-1 (May 2026)2,339 adults with obesity, 80 weeks−28.3% (12 mg), −25.9% (9 mg), −19.0% (4 mg); 30.3% at 104 weeks in an extension group
TRIUMPH-2 (Jul 2026)Obesity with type 2 diabetes−20.8% weight and −1.5 point A1C change at 12 mg
TRIUMPH-3 (Jul 2026)Obesity with cardiovascular disease−22.6% mean weight change at 12 mg
TRANSCEND-T2D-2 (Oct 2026)1,298 adults with type 2 diabetes, vs semaglutide 2 mg, 80 weeksA1C −2.2 vs −1.8 points; weight −20.9% (12 mg) vs −9.4% with semaglutide

Tolerability in TRIUMPH-1

Gastrointestinal effects were the most common adverse events. Lilly reported nausea in 42.4% of participants in the 12 mg arm versus 14.8% with placebo. Adverse events led to discontinuation in 11.3% at 12 mg versus 4.9% with placebo. Dose escalation was used in all arms, which is why trial results are reported by target dose.

First head-to-head comparison with semaglutide

TRANSCEND-T2D-2 is the first Phase 3 trial to compare retatrutide directly with another incretin medicine. In adults with type 2 diabetes, retatrutide lowered A1C and body weight more than semaglutide 2 mg over 80 weeks. A direct comparison with tirzepatide has not been reported, so tirzepatide-versus-retatrutide comparisons still rely on separate trials with different populations.

Regulatory status in Canada and the U.S.

Retatrutide is not approved by Health Canada, the FDA or any other regulator, and no pharmacy or prescription product exists. Lilly has said it plans to file with the FDA in the first quarter of 2027. Until a product is authorized, retatrutide sold in Canada is a research chemical only. See our analysis of the filing target.

Mechanism in brief

Retatrutide (LY3437943) is a single 39-amino-acid peptide that activates three receptors: GIP, GLP-1 and glucagon. Semaglutide acts on GLP-1 alone and tirzepatide on GIP and GLP-1. The added glucagon-receptor activity is thought to raise energy expenditure and reduce liver fat, which is why researchers sometimes call it a "GLP-3" or triple agonist. Its half-life of about six days supports once-weekly dosing in trials.

Key sources

  1. Coskun T et al. LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist. Cell Metab 2022. PMID 35985340
  2. Urva S et al. LY3437943 in people with type 2 diabetes: a phase 1b trial. Lancet 2022. PMID 36354040
  3. Jastreboff AM et al. Triple-hormone-receptor agonist retatrutide for obesity — a phase 2 trial. N Engl J Med 2023. PMID 37366315
  4. Rosenstock J et al. Retatrutide for people with type 2 diabetes. Lancet 2023. PMID 37385280
  5. Sanyal AJ et al. Retatrutide for metabolic dysfunction-associated steatotic liver disease. Nat Med 2024. PMID 38858523
  6. TRIUMPH-1, ClinicalTrials.gov NCT05929066; Eli Lilly press releases, December 2025 to October 2026.

Last updated · Reviewed against PubMed, trial registries and regulator sources

Frequently Asked Questions

Where can I buy retatrutide in Canada?
Anglo Peptides sells retatrutide as a research peptide on this page. Choose a vial size and check out. Orders ship within Canada by Canada Post Xpresspost with tracking. A third-party COA for each lot is available through the Certificate of Analysis page.
How much does retatrutide cost in Canada?
Current prices in Canadian dollars: 5 mg: $63.99 · 10 mg: $87.99 · 30 mg: $187.99 · 60 mg: $297.99. Prices are per lyophilized vial, and stock status updates when you select a size.
What retatrutide vial sizes are available?
Retatrutide is listed in 5 mg, 10 mg, 30 mg and 60 mg lyophilized vials. The number is the nominal peptide content of the vial, not a dose. Use the peptide calculator to work out concentration after reconstitution.
Is retatrutide available in Canada?
Not as an approved medicine. Retatrutide (LY3437943) is still in Phase 3 clinical trials and has not been approved by Health Canada, so in Canada it is only available as a research peptide like this one. For laboratory research use only; not for human or veterinary use. See Are peptides legal in Canada? for how research peptides are regulated.

More retatrutide questions

What dosages of retatrutide were used in clinical trials?

Phase 3 TRIUMPH and TRANSCEND trials tested once-weekly target doses of 4 mg, 9 mg and 12 mg, reached by stepping up from a lower starting dose every four weeks. The Phase 2 obesity trial also tested 1 mg and 8 mg arms. These are trial protocols for Lilly's investigational medicine. They are not dosing instructions, and this product is sold for laboratory research only. For vial arithmetic, use the peptide calculator.

What side effects of retatrutide were reported in trials?

The most common adverse events were gastrointestinal: nausea, diarrhea, vomiting and constipation, mostly during dose escalation. In TRIUMPH-1, nausea affected 42.4% at 12 mg versus 14.8% on placebo, and 11.3% stopped treatment because of adverse events versus 4.9% on placebo. Phase 2 trials also reported dose-related increases in heart rate. Long-term safety data are still being collected.

What results did retatrutide show in trials?

In TRIUMPH-1, adults with obesity lost a mean 28.3% of body weight on 12 mg over 80 weeks, and 30.3% at 104 weeks in an extension group. In adults with type 2 diabetes, TRANSCEND-T2D-2 reported a 20.9% weight reduction and a 2.2-point A1C drop, versus 9.4% and 1.8 points with semaglutide 2 mg.

How does tirzepatide compare with retatrutide?

Tirzepatide activates GIP and GLP-1 receptors; retatrutide adds glucagon receptor activity. Tirzepatide is approved in Canada as Mounjaro and Zepbound, while retatrutide is still investigational. Their trial results come from separate studies, so the figures cannot be compared directly. Our tirzepatide vs retatrutide guide sets the trials side by side.

When will retatrutide be available in Canada?

No date has been set. Lilly plans to file in the U.S. in the first quarter of 2027, and a Health Canada submission would follow its own review timeline, usually about a year once filed. Until then, retatrutide cannot be prescribed in Canada and is sold only as a research chemical.

Is retatrutide FDA approved?

No. As of November 2026, retatrutide is not approved by the FDA, Health Canada, the EMA or any other regulator. Lilly has said it plans to submit to the FDA in the first quarter of 2027.

Is there a retatrutide pen?

No retatrutide pen is sold or approved anywhere. Trial participants received Lilly's investigational product under study conditions. Products sold online as "retatrutide pens" are not authorized medicines. Anglo Peptides supplies retatrutide only as lyophilized powder in sealed research vials.

Why is retatrutide called a GLP-3 or triple agonist?

"GLP-3" is an informal nickname, not a scientific term; there is no GLP-3 hormone. Retatrutide is a triple agonist because one molecule activates GIP, GLP-1 and glucagon receptors. Semaglutide is a single agonist (GLP-1) and tirzepatide a dual agonist (GIP and GLP-1).

How do you reconstitute retatrutide?

Lyophilized retatrutide is usually reconstituted with bacteriostatic water, added slowly down the vial wall and swirled gently rather than shaken. The volume sets the concentration: for example, 2 mL in a 10 mg vial gives 5 mg/mL. Our retatrutide reconstitution guide has a chart for 5, 10, 30 and 60 mg vials.

How do I get retatrutide in Canada for research?

Choose the vial size above (5, 10, 30 or 60 mg) and check out; orders ship within Canada. Each lot has a batch-specific analytical report that you can request before or after ordering. Retatrutide is sold for laboratory research only, and we do not sell it for human use or supply it to individuals for self-administration.

How did trials limit nausea with retatrutide?

Trials started at a low dose and increased it every four weeks, because nausea was most common during escalation. Phase 2 data showed lower rates with a lower starting dose. This describes trial design only and is not medical advice.

Is retatrutide a peptide?

Yes. Retatrutide is a 39-amino-acid synthetic peptide with a fatty-acid side chain that binds albumin and extends its half-life to about six days. Tirzepatide and semaglutide are built the same way.

7 reviews for Retatrutide Research Peptide Canada — 5mg, 10mg, 30mg & 60mg

  1. James T. –

    Second time ordering reta from Anglo and the quality is still the best I’ve found in Canada. Powder reconstituted perfectly, clear solution every time. Had it in two days. Solid company all around.

  2. Priya S. –

    Best retatrutide I have tried from a Canadian source. Came same day, packaging was tight, reconstituted with no issues. On my third vial now and the quality is the same every time.

  3. Omar K. –

    Really impressed. Came packaged well and shipped same day. The 10mg vial is great value compared to what I was paying at other sources. Anglo is my go-to now.

  4. Wei L. –

    Good product, shipped quick. Had it within 48 hours of ordering, reconstituted cleanly with no cloudiness. Only wish they offered a larger vial option but the quality is solid.

  5. Luke A. –

    Ordered late Wednesday, had it Thursday. Clean powder, dissolved perfectly. Anglo is the real deal for reta in Canada, nothing else comes close at this price.

  6. Olivia T. –

    Incredibly rare to find research-grade Retatrutide made in Canada. Anglo Peptides nailed it, proper COA from Janoshik, clean reconstitution, and lightning-fast Xpresspost shipping.

  7. Henry S. –

    The 10mg vial is excellent. Dissolved cleanly and the documentation is thorough. Knowing it is manufactured in Canada gives me a lot of confidence in the supply chain.

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